Melamine

cat severe

Go to the vet immediately — don't wait for symptoms.

dog severe

Go to the vet immediately — don't wait for symptoms.

Confidence: high
Summary: Melamine is a nitrogen-containing organic compound that has been found as a contaminant in pet food; when co-ingested with cyanuric acid (a structural analogue and common co-contaminant), it forms insoluble crystals in the distal renal tubules, causing acute kidney failure. In the 2007 pet food recall, hundreds of cats and dogs developed nephrotoxic renal failure, with documented signs including inappetence, vomiting, polyuria, polydipsia, lethargy, and azotemia; deaths and euthanasias were recorded. Multiple peer-reviewed veterinary and toxicological studies confirm that the combination of melamine and cyanuric acid is responsible for the acute renal injury, with cats and male rats identified as particularly susceptible species.
Trend Term: Melamine

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